Solubilization of cyclosporin A
نویسندگان
چکیده
منابع مشابه
Cyclosporin A and Cyclosporin SDZ
Recent studies have shown that cyclosporin A (CsA) may affect ricin A-chain immunotoxin (RTA-IT) therapy. In this study, we evaluated the ability of CsA and its nonirnmunosuppressive analog. SDZ PSC 833, to enhance anti-CD5 T l O l RTA-ITS in vitro. Both 4 pmol/L CsA and 4 pmol/L SDZ PSC 833 significantly and specifically enhanced the cytotoxic activity of T101 RTA-IT on the human lymphoblastic...
متن کاملCyclosporin A and Cyclosporin SDZ
Recent studies have shown that cyclosporin A (CsA) may affect ricin A-chain immunotoxin (RTA-IT) therapy. In this study, we evaluated the ability of CsA and its nonirnmunosuppressive analog. SDZ PSC 833, to enhance anti-CD5 T l O l RTA-ITS in vitro. Both 4 pmol/L CsA and 4 pmol/L SDZ PSC 833 significantly and specifically enhanced the cytotoxic activity of T101 RTA-IT on the human lymphoblastic...
متن کاملSTRUCTURAL ANALYSIS OF CYCLOSPORIN-A BY RAMAN TECHNIQUE
The Raman spectrum of cyclosporin-A has been recorded in the solid phase. The conformation of the molecule has been discussed on the basis of Raman data. It has been concluded that in agreement with X-ray data, cyclosporin-A molecule has an antiparallel P- pleated sheet conformation. It may have some reverse P- turn structure in what has been assigned to a random coil conformation.
متن کاملA Study of arbutin protective effect on cyclosporin A-induced oxidative damage
Background: Cyclosporine A (CsA) is a potent immunosuppressant drug with therapeutic and toxic actions. The use of CsA is limited by its toxicity. Several researchers had proposed that oxidative stress could play an important role in CsA-induced toxicity. Arbutin has recently been shown to possess antioxidative and free radical scavenging abilities.The present study was designed to investigate...
متن کاملSilymarin flavonoids and cyclosporin A: Effective co-therapy?
Milk thistle (Silybum marianum) is a native plant of Mediterranean Sea areas. Silymarin, an extract from its seeds, is used in various liver diseases for its hepatoprotective effects. It contains silymarin flavonoids (SF) such as silybin, silydianin and silychristin. Cyclosporin A (CsA) is widely used as an immunosuppressant in organ transplantations. Its other applications in many autoimmune d...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2001
ISSN: 1530-9932
DOI: 10.1208/pt020102